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Article

Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas.

Oncology reports - 1 Jan 2000

Gonzalez-Gomez Pilar, Bello M Josefa, Arjona Dolores, Alonso M Eva, Lomas Jesus, De Campos Jose M, Vaquero Jesus, Isla Alberto, Gutierrez Manuel, Rey Juan A

Abstract excerpt

The retinoblastoma gene family RB1, p107 and RB2/p130 cooperate to regulate cell cycle progression through the G1 phase of the cell cycle. Previous data demonstrated that RB2/p130 inhibits proliferation of the glioblastoma cell line T98G, which is resistant to the growth suppressive effects of both RB1 and p107, and that RB2/p130 gene overexpresion induces astrocyte differentiation. We screened by single-strand...

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PMID: 12168053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas.PMID 12168053Read ↗

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Reduced transcription of the RB2/p130 gene in human lung cancer.Semantic proximity Read ↗

miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma.Semantic proximity Read ↗

Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer.Semantic proximity Read ↗

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