Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer.

Article

Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer.

Cancer research - 15 Aug 1996

Foster K A, Harrington P, Kerr J, Russell P, DiCioccio R A, Scott I V, Jacobs I, Chenevix-Trench G, Ponder B A, Gayther S A

Abstract excerpt

The breast and ovarian cancer susceptibility gene BRCA2 has recently been isolated. A role for BRCA2 in sporadic breast and ovarian cancer has been suggested by loss of heterozygosity (LOH) studies which show frequent LOH in the BRCA2 region at chromosome 13q12. In addition, the observation of no...

Topics

BRCA2 Protein
Chromosome Deletion
Female
Humans
Mutation
Neoplasm Proteins
Ovarian Neoplasms
Transcription Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.