Article
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
The EMBO journal - 3 Jun 2002
Kirsh Olivier, Seeler Jacob-S, Pichler Andrea, Gast Andreas, Müller Stefan, Miska Eric, Mathieu Marion, Harel-Bellan Annick, Kouzarides Tony, Melchior Frauke, Dejean Anne
Abstract excerpt
Transcriptional repression mediated through histone deacetylation is a critical component of eukaryotic gene regulation. Here we demonstrate that the class II histone deacetylase HDAC4 is covalently modified by the ubiquitin-related SUMO-1 modifier. A sumoylation-deficient point mutant (HDAC4-K559R) shows a slightly impaired ability to repress transcription as well as reduced histone deacetylase activity. The...
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