Article
SUMOylation modulates the transcription repressor function of RIP140.
The Journal of biological chemistry - 25 Apr 2008
Rytinki Miia M, Palvimo Jorma J
Abstract excerpt
RIP140/NRIP1 (receptor-interacting protein 140) functions as a corepressor of nuclear receptors. It plays an important role in the transcriptional control of energy metabolism and female fertility. RIP140 contains four distinct repression domains (RD1-RD4), and the repressive activity of RIP140 involves complex mechanisms. The function of both RD1 and RD2 is linked to recruitment of histone deacetylases and...
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