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Article

Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.

Molecular and cellular biology - 1 Oct 2005

Zhao Xuan, Sternsdorf Thomas, Bolger Timothy A, Evans Ronald M, Yao Tso-Pang

Abstract excerpt

The class II deacetylase histone deacetylase 4 (HDAC4) negatively regulates the transcription factor MEF2. HDAC4 is believed to repress MEF2 transcriptional activity by binding to MEF2 and catalyzing local histone deacetylation. Here we report that HDAC4 also controls MEF2 by a novel SUMO E3 ligase activity. We show that HDAC4 interacts with the SUMO E2 conjugating enzyme Ubc9 and is itself sumoylated. The...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 16166628
DOI: 10.1128/MCB.25.19.8456-8464.2005
PMCID: PMC1265742

Genes

HDAC4
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.PMID 16166628Read ↗

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