Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation.

The Journal of biological chemistry - 17 Aug 2012

Liu Yuanjing, Peng Lirong, Seto Edward, Huang Suming, Qiu Yi

Abstract excerpt

The reversible acetylation of histones and non-histone proteins by histone acetyltransferases and deacetylases (HDACs) plays a critical role in many cellular processes in eukaryotic cells. HDAC6 is a unique histone deacetylase with two deacetylase domains and a C-terminal zinc finger domain. HDAC6 resides mainly in the cytoplasm and regulates many important biological processes, including cell migration and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Active Transport, Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to alpha Karyopherins

Share to Histone Deacetylases

Share to Nuclear Localization Signals

Share to p300-CBP Transcription Factors

Share to Protein Processing, Post-Translational

Share to Tubulin

Source

Open in PubMed Open full text

Identifiers

PMID: 22778253
DOI: 10.1074/jbc.M112.371120
PMCID: PMC3436516

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation.PMID 22778253Read ↗

Histone Deacetylase 6 in Health and DiseaseSemantic proximity Read ↗

HDAC6 Substrate Discovery Using Proteomics-Based Substrate Trapping: HDAC6 Deacetylates PRMT5 to Influence Methyltransferase Activity.Semantic proximity Read ↗

Interplay Between HDAC6 and Its Interacting Partners: Essential Roles in the Aggresome-Autophagy Pathway and Neurodegenerative DiseasesSemantic proximity Read ↗

HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscapeSemantic proximity Read ↗

Histone deacetylase 6 in cancerSemantic proximity Read ↗

Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathwaysSemantic proximity Read ↗

HDAC6 and Ovarian CancerSemantic proximity Read ↗

Novel nuclear role of HDAC6 in prognosis and therapeutic target for colorectal cancerSemantic proximity Read ↗

The therapeutic hope for HDAC6 inhibitors in malignancy and chronic diseaseSemantic proximity Read ↗

Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease.Semantic proximity Read ↗

The diversity of acetylated proteins.Semantic proximity Read ↗

Cloning and Functional Characterization of HDAC11, a Novel Member of the Human Histone Deacetylase FamilySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.