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Article

P300 transcriptional repression is mediated by SUMO modification.

Molecular cell - 1 Apr 2003

Girdwood David, Bumpass Donna, Vaughan Owen A, Thain Alison, Anderson Lisa A, Snowden Andrew W, Garcia-Wilson Elisa, Perkins Neil D, Hay Ronald T

Abstract excerpt

p300 and CREB binding protein can both activate and repress transcription. Here, we locate the CRD1 transcriptional repression domain between residues 1017 and 1029 of p300. This region contains two copies of the sequence psiKxE that are modified by the ubiquitin-like protein SUMO-1. Mutations that reduce SUMO modification increase p300-mediated transcriptional activity and expression of a SUMO-specific protease...

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Source

Identifiers

PMID: 12718889
DOI: 10.1016/s1097-2765(03)00141-2

Genes

HDAC6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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