Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.

Molecular and cellular biology - 1 Mar 2005

Grégoire Serge, Yang Xiang-Jiao

Abstract excerpt

The myocyte enhancer factor-2 (MEF2) family of transcription factors plays an important role in regulating cellular programs like muscle differentiation, neuronal survival, and T-cell apoptosis. Multisite phosphorylation is known to control the transcriptional activity of MEF2 proteins, but it is unclear whether other modifications are involved. Here, we report that human MEF2D, as well as MEF2C, is modified by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinases
Share to Cysteine Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endopeptidases

Share to Histone Deacetylases

Share to MADS Domain Proteins

Share to MEF2 Transcription Factors

Share to Myogenic Regulatory Factors

Share to Small Ubiquitin-Related Modifier Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 15743823
DOI: 10.1128/MCB.25.6.2273-2287.2005
PMCID: PMC1061617

Genes

HDAC4
HDAC5
HDAC7
HDAC9
SENP3
SUMO2
SUMO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.PMID 15743823Read ↗

SUMO-1 modification of MEF2A regulates its transcriptional activity.Semantic proximity Read ↗

Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.Semantic proximity Read ↗

Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation.Semantic proximity Read ↗

Sumoylation: a regulatory protein modification in health and disease.Semantic proximity Read ↗

SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4.Semantic proximity Read ↗

SUMO-1 modification activated GATA4-dependent cardiogenic gene activity.Semantic proximity Read ↗

SUMO--a post-translational modification with therapeutic potential?Semantic proximity Read ↗

Epigenetic regulation of skeletal muscle development and differentiation.Semantic proximity Read ↗

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.Semantic proximity Read ↗

SUMOylation in Skeletal Development, Homeostasis, and DiseaseSemantic proximity Read ↗

Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.Semantic proximity Read ↗

Sumoylation and Regulation of Cardiac Gene ExpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.