Article
The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.
Oncogene - 1 Mar 2021
Blondel-Tepaz Elodie, Leverve Marie, Sokrat Badr, Paradis Justine S, Kosic Milena, Saha Kusumika, Auffray Cédric, Lima-Fernandes Evelyne, Zamborlini Alessia, Poupon Anne, Gaboury Louis, Findlay Jane, Baillie George S, Enslen Hervé, Bouvier Michel, Angers Stéphane, Marullo Stefano, Scott Mark G H
Abstract excerpt
Mdm2 antagonizes the tumor suppressor p53. Targeting the Mdm2-p53 interaction represents an attractive approach for the treatment of cancers with functional p53. Investigating mechanisms underlying Mdm2-p53 regulation is therefore important. The scaffold protein β-arrestin2 (β-arr2) regulates tumor suppressor p53 by counteracting Mdm2. β-arr2 nucleocytoplasmic shuttling displaces Mdm2 from the nucleus to the...
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