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Article

Ikaros SUMOylation: switching out of repression.

Molecular and cellular biology - 1 Apr 2005

Gómez-del Arco Pablo, Koipally Joseph, Georgopoulos Katia

Abstract excerpt

Ikaros plays a key role in lymphocyte development and homeostasis by both potentiating and repressing gene expression. Here we show that Ikaros interacts with components of the SUMO pathway and is SUMOylated in vivo. Two SUMOylation sites are identified on Ikaros whose simultaneous modification results in a loss of Ikaros' repression function. Ikaros SUMOylation disrupts its participation in both histone...

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Identifiers

PMID: 15767674
DOI: 10.1128/MCB.25.7.2688-2697.2005
PMCID: PMC1061640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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