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Article

Identification of two novel regulated serines in the N terminus of beta-catenin.

Experimental cell research - 10 Jun 2002

van Noort Mascha, van de Wetering Marc, Clevers Hans

Abstract excerpt

Beta-catenin plays a key role in the Wnt signaling cascade. The levels of beta-catenin within a cell are regulated via phosphorylation of the N terminus of beta-catenin by GSK-3beta. The phosphorylation leads to ubiquitination and subsequent degradation of the protein. Thus far three serines (S33, 37, 45) and one threonine (T41) are considered to be the substrates for GSK-3beta phosphorylation. Indeed, these...

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Identifiers

PMID: 12027456
DOI: 10.1006/excr.2002.5520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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