Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Threonine 393 of beta-catenin regulates interaction with Axin.

Journal of cellular biochemistry - 1 Sept 2009

Wu Hao, Symes Karen, Seldin David C, Dominguez Isabel

Abstract excerpt

CK2 is a regulatory kinase implicated in embryonic development and in cancer. Among the CK2 substrates is beta-catenin, a protein with dual function in Wnt signaling and cell adhesion. Previously, we reported that CK2 activity is required for beta-catenin stability and we identified threonine (T) 393 as a major CK2 phosphorylation site in beta-catenin. However, it is not known whether phosphorylation at T393...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to Axin Protein
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Threonine

Share to Transcriptional Activation

Share to Xenopus

Share to Xenopus Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19565571
DOI: 10.1002/jcb.22260
PMCID: PMC3398408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Threonine 393 of beta-catenin regulates interaction with Axin.PMID 19565571Read ↗

Threonine 41 in beta-catenin serves as a key phosphorylation relay residue in beta-catenin degradation.Semantic proximity Read ↗

Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin.Semantic proximity Read ↗

The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1.Semantic proximity Read ↗

Identification of two novel regulated serines in the N terminus of beta-catenin.Semantic proximity Read ↗

Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites.Semantic proximity Read ↗

Phosphorylation and regulation of beta-catenin by casein kinase I epsilon.Semantic proximity Read ↗

CK2 as a positive regulator of Wnt signalling and tumourigenesis.Semantic proximity Read ↗

Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation.Semantic proximity Read ↗

Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional activity.Semantic proximity Read ↗

A mode of regulation of beta-catenin signaling activity in Xenopus embryos independent of its levels.Semantic proximity Read ↗

Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer.Semantic proximity Read ↗

p120-catenin phosphorylation status alters E-cadherin mediated cell adhesion and ability of tumor cells to metastasize.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.