Article
The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2006
Bustos Victor H, Ferrarese Anna, Venerando Andrea, Marin Oriano, Allende Jorge E, Pinna Lorenzo A
Abstract excerpt
Multiple phosphorylation of beta-catenin by glycogen synthase kinase 3 (GSK3) in the Wnt pathway is primed by CK1 through phosphorylation of Ser-45, which lacks a typical CK1 canonical sequence. Synthetic peptides encompassing amino acids 38-64 of beta-catenin are phosphorylated by CK1 on Ser-45 with low affinity (K(m) approximately 1 mM), whereas intact beta-catenin is phosphorylated at Ser-45 with very high...
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