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Article

Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells.

The Journal of biological chemistry - 28 Jun 2002

Hagen Thilo, Di Daniel Elena, Culbert Ainsley A, Reith Alastair D

Abstract excerpt

Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase that is involved in multiple cellular signaling pathways, including the Wnt signaling cascade where it phosphorylates beta-catenin, thus targeting it for proteasome-mediated degradation. Unlike phosphorylation of glycogen synthase, p...

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Source

Identifiers

PMID: 11967263
DOI: 10.1074/jbc.M201364200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11967263-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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