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Article

Threonine 41 in beta-catenin serves as a key phosphorylation relay residue in beta-catenin degradation.

Biochemistry - 25 Apr 2006

Wu Geng, He Xi

Abstract excerpt

Beta-catenin phosphorylation at serine 45 (Ser45), threonine 41 (Thr41), Ser37, and Ser33 is critical for beta-catenin degradation, and regulation of beta-catenin phosphorylation is a central part of the canonical Wnt signaling pathway. Beta-catenin mutations at Ser45, Thr41, Ser37, and Ser33 perturb beta-catenin degradation and are frequently found in cancers. It is established that Ser45 phosphorylation by...

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Identifiers

PMID: 16618120
DOI: 10.1021/bi0601149

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