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Article

Analysis of β-catenin alterations in colon tumors: a novel exon 3 mutation.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2011

Akisik Elif, Buğra Dursun, Yamaner Sumer, Dalay Nejat

Abstract excerpt

The great majority of colorectal cancers have defects in the Wnt signaling pathway indicating that this pathway has an important role in carcinogenesis. Alterations in the β-catenin gene are observed in 10-50% of the patients with colorectal cancer. Mutations of the β-catenin gene frequently occur in a region coding the protein phosphorylation domain harboring the Ser33/37/Thr41 and Ser45 sites and the inhibition...

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Identifiers

PMID: 20717765
DOI: 10.1007/s13277-010-0099-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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