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Article

Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites.

The Journal of biological chemistry - 22 Aug 2003

Provost Elayne, Yamamoto Yumi, Lizardi Isabel, Stern Jessica, D'Aquila Thomas G, Gaynor Richard B, Rimm David L

Abstract excerpt

beta-Catenin-mediated signaling can be constitutively activated by truncation or mutation of serine and threonine residues in exon 3. Mutations in this region are observed in many human tumors. Examination of the locations of these mutations reveals interesting patterns; specifically, Ser45 and Thr41 appear more frequently in malignant tumors, and Ser37 and Ser33 are more common in benign entities. To test...

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PMID: 12799363
DOI: 10.1074/jbc.M304953200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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