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Article

Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin.

Oncogene - 14 Apr 2005

Provost Elayne, McCabe Anthony, Stern Jessica, Lizardi Isabel, D'Aquila Thomas G, Rimm David L

Abstract excerpt

Beta-catenin is a multifunctional protein involved in both cadherin-mediated adhesion and the wnt signaling cascade. Mutations in exon 3 of beta-catenin have been identified in many cancers. In addition to disruption of key serine and threonine residues, mutations are frequently reported in other residues in exon 3 that are not kinase substrates. The most frequently mutated nonserine/threonine residues are D32...

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PMID: 15829978
DOI: 10.1038/sj.onc.1208346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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