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Article

Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.

Nature - 23 May 2002

Cheng Michelle Y, Bullock Clayton M, Li Chuanyu, Lee Alex G, Bermak Jason C, Belluzzi James, Weaver David R, Leslie Frances M, Zhou Qun-Yong

Abstract excerpt

The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. Here we show that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have...

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PMID: 12024206
DOI: 10.1038/417405a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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