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Article

The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations.

Endocrine reviews - 1 Apr 2011

Martin Cecilia, Balasubramanian Ravikumar, Dwyer Andrew A, Au Margaret G, Sidis Yisrael, Kaiser Ursula B, Seminara Stephanie B, Pitteloud Nelly, Zhou Qun-Yong, Crowley William F

Abstract excerpt

A widely dispersed network of hypothalamic GnRH neurons controls the reproductive axis in mammals. Genetic investigation of the human disease model of isolated GnRH deficiency has revealed several key genes crucial for GnRH neuronal ontogeny and GnRH secretion. Among these genes, prokineticin 2 (PROK2), and PROK2 receptor (PROKR2) have recently emerged as critical regulators of reproduction in both mice and...

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Mice
Mice, Knockout
Models, Animal
Neuropeptides
Receptors, G-Protein-Coupled

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Peptide

Signal Transduction

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Open in PubMed Open full text

Identifiers

PMID: 21037178
DOI: 10.1210/er.2010-0007
PMCID: PMC3365793

Genes

PROK2
PROKR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations.PMID 21037178Read ↗

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