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Article

PROK2/PROKR2 Signaling and Kallmann Syndrome

1 Jan 2013

Abstract excerpt

Kallmann syndrome (KS) is a developmental disease that associates hypogonadism and a deficiency of the sense of smell. The reproductive phenotype of KS results from the primary interruption of the olfactory, vomeronasal, and terminal nerve fibers in the frontonasal region, which in turn disrupts the embryonic migration of neuroendocrine gonadotropin-releasing hormone (GnRH) synthesizing cells from the nose to the...

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PMID: 23596439
DOI: 10.3389/fendo.2013.00019

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