Article
The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism.
Neuroendocrinology - 1 Jan 2010
Abreu Ana Paula, Kaiser Ursula B, Latronico Ana Claudia
Abstract excerpt
The prokineticin system comprises two multifunctional secreted proteins, prokineticin-1 (PROK1) and prokineticin-2 (PROK2), and their cognate G protein-coupled receptors. The prokineticins were originally identified as endogenous regulators of gastrointestinal motility. Currently, these bioactive peptides are involved in a wide spectrum of biological functions, including angiogenesis, neurogenesis, circadian...
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