Article
New roles for prokineticin 2 in feeding behavior, insulin resistance and type 2 diabetes: Studies in mice and humans.
Molecular metabolism - 1 Nov 2019
Mortreux Marie, Foppen Ewout, Denis Raphaël G, Montaner Mireia, Kassis Nadim, Denom Jessica, Vincent Mylène, Fumeron Frédéric, Kujawski-Lafourcade Margaux, Andréelli Fabrizio, Balkau Beverley, Marre Michel, Roussel Ronan, Magnan Christophe, Gurden Hirac, Migrenne-Li Stéphanie
Abstract excerpt
OBJECTIVE: Prokineticin 2 (PROK2) is a hypothalamic neuropeptide that plays a critical role in the rhythmicity of physiological functions and inhibits food intake. PROK2 is also expressed in the main olfactory bulb (MOB) as an essential factor for neuro-and morphogenesis. Since the MOB was shown to be strongly involved in eating behavior, we hypothesized that PROK2 could be a new target in the regulation of food...
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