Article
Loss of prokineticin receptor 2 signaling predisposes mice to torpor.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jun 2008
Jethwa Preeti H, I'Anson Helen, Warner Amy, Prosser Hayden M, Hastings Michael H, Maywood Elizabeth S, Ebling Francis J P
Abstract excerpt
The genes encoding prokineticin 2 polypeptide (Prok2) and its cognate receptor (Prokr2/Gpcr73l1) are widely expressed in both the suprachiasmatic nucleus and its hypothalamic targets, and this signaling pathway has been implicated in the circadian regulation of behavior and physiology. We have previously observed that the targeted null mutation of Prokr2 disrupts circadian coordination of cycles of locomotor...
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