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Article

Systematic Characterization and Comparative Analysis of the Rabbit Immunoglobulin Repertoire

30 Jun 2014

Abstract excerpt

Rabbits have been used extensively as a model system for the elucidation of the mechanism of immunoglobulin diversification and for the production of antibodies. We employed Next Generation Sequencing to analyze Ig germline V and J gene usage, CDR3 length and amino acid composition, and gene conversion frequencies within the functional (transcribed) IgG repertoire of the New Zealand white rabbit (Oryctolagus...

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PMID: 24978027
DOI: 10.1371/journal.pone.0101322

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