Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene conversion and hypermutation during diversification of VH sequences in developing splenic germinal centers of immunized rabbits.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1999

Schiaffella E, Sehgal D, Anderson A O, Mage R G

Abstract excerpt

The young rabbit appendix and the chicken bursa of Fabricius are primary lymphoid organs where the B cell Ab repertoire develops in germinal centers (GCs) mainly by a gene conversion-like process. In human and mouse, V-gene diversification by somatic hypermutation in GCs of secondary lymphoid organs leads to affinity maturation. We asked whether gene conversion, somatic hypermutation, or both occur in rabbit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to B-Lymphocytes

Share to Base Sequence

Share to Clone Cells

Share to Molecular Sequence Data

Share to Mutation

Share to Rabbits

Source

Identifiers

PMID: 10201919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene conversion and hypermutation during diversification of VH sequences in developing splenic germinal centers of immunized rabbits.PMID 10201919Read ↗

Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

Gene-conversion in rabbit B-cell ontogeny and during immune responses in splenic germinal centers.Semantic proximity Read ↗

Generation of heterogeneous rabbit anti-DNP antibodies by gene conversion and hypermutation of rearranged VL and VH genes during clonal expansion of B cells in splenic germinal centers.Semantic proximity Read ↗

Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

Antigen-Induced Somatic Diversification of Rabbit IgH Genes: Gene Conversion and Point MutationSemantic proximity Read ↗

Somatic hypermutation: mutations 3' of rabbit VDJ H-chain genes.Semantic proximity Read ↗

Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection.Semantic proximity Read ↗

Immunoglobulin gene conversion identification and analysisSemantic proximity Read ↗

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.Semantic proximity Read ↗

Distinct clonal Ig diversification patterns in young appendix compared to antigen-specific splenic clones.Semantic proximity Read ↗

Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion.Semantic proximity Read ↗

Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.