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Article

Gene conversion and hypermutation during diversification of VH sequences in developing splenic germinal centers of immunized rabbits.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1999

Schiaffella E, Sehgal D, Anderson A O, Mage R G

Abstract excerpt

The young rabbit appendix and the chicken bursa of Fabricius are primary lymphoid organs where the B cell Ab repertoire develops in germinal centers (GCs) mainly by a gene conversion-like process. In human and mouse, V-gene diversification by somatic hypermutation in GCs of secondary lymphoid organs leads to affinity maturation. We asked whether gene conversion, somatic hypermutation, or both occur in rabbit...

Topics

Amino Acid Sequence
Amino Acid Substitution
Animals
Antibody Diversity
B-Lymphocytes
Base Sequence
Clone Cells
Gene Conversion
Germinal Center
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Rabbits

Spleen

Source

Identifiers

PMID: 10201919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10201919-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Gene conversion and hypermutation during diversification of VH sequences in developing splenic germinal centers of immunized rabbits.PMID 10201919Read ↗

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