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Article

Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.

Molecular biology of the cell - 1 May 2002

Chung Eunah, Chen Rey-Huei

Abstract excerpt

The spindle checkpoint prevents anaphase from occurring until all chromosomes have attached properly to the mitotic spindle. The checkpoint components Mad1 and Mad2 associate with unattached kinetochores and are probably involved in triggering the checkpoint. We now demonstrate that in Xenopus egg extracts Mad1 and Mad2 form a stable complex, whereas a fraction of Mad2 molecules is not bound to Mad1. The...

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Identifiers

PMID: 12006648
DOI: 10.1091/mbc.02-01-0003
PMCID: PMC111122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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