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Article

NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.

The Journal of biological chemistry - 7 May 2004

Lou Yang, Yao Jianhui, Zereshki Arzhang, Dou Zhen, Ahmed Kashif, Wang Hongmei, Hu Junbin, Wang Yuzhen, Yao Xuebiao

Abstract excerpt

Chromosome segregation in mitosis is orchestrated by protein kinase signaling cascades. A biochemical cascade named spindle checkpoint ensures the spatial and temporal order of chromosome segregation during mitosis. Here we report that spindle checkpoint protein MAD1 interacts with NEK2A, a human orthologue of the Aspergillus nidulans NIMA kinase. MAD1 interacts with NEK2A in vitro and in vivo via a leucine...

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Identifiers

PMID: 14978040
DOI: 10.1074/jbc.M314205200

Genes

BUB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.PMID 14978040Read ↗

The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.Semantic proximity Read ↗

Cell cycle regulation by the NEK family of protein kinasesSemantic proximity Read ↗

A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint.Semantic proximity Read ↗

A mitotic role for Mad1 beyond the spindle checkpoint.Semantic proximity Read ↗

Mitotic checkpoint proteins Mad1 and Mad2 - structural and functional relationship with implication in genetic diseases.Semantic proximity Read ↗

Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila S2 cells.Semantic proximity Read ↗

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.Semantic proximity Read ↗

Spindle checkpoint signaling requires the mis6 kinetochore subcomplex, which interacts with mad2 and mitotic spindles.Semantic proximity Read ↗

Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulans.Semantic proximity Read ↗

Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2.Semantic proximity Read ↗

Bub1 regulates chromosome segregation in a kinetochore-independent manner.Semantic proximity Read ↗

Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.Semantic proximity Read ↗

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