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Article

Mad2 phosphorylation regulates its association with Mad1 and the APC/C.

The EMBO journal - 17 Feb 2003

Wassmann Katja, Liberal Vasco, Benezra Robert

Abstract excerpt

Improper attachment of the mitotic spindle to the kinetochores of paired sister chromatids in mitosis is monitored by a checkpoint that leads to an arrest in early metaphase. This arrest requires the inhibitory association of Mad2 with the anaphase promoting complex/cyclosome (APC/C). It is not known how the association of Mad2 with the kinetochore and the APC/C is regulated in mitosis. Here, we demonstrate that...

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Identifiers

PMID: 12574116
DOI: 10.1093/emboj/cdg071
PMCID: PMC145433

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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