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The Mad1–Mad2 balancing act – a damaged spindle checkpoint in chromosome instability and cancer

1 Jan 2012

Abstract excerpt

Cancer cells are commonly aneuploid. The spindle checkpoint ensures accurate chromosome segregation by controlling cell cycle progression in response to aberrant microtubule-kinetochore attachment. Damage to the checkpoint, which is a partial loss or gain of checkpoint function, leads to aneuploidy during tumorigenesis. One form of damage is a change in levels of the checkpoint proteins mitotic arrest deficient 1...

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PMID: 23093575
DOI: 10.1242/jcs.107037

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