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Article

Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation.

Journal of cell science - 1 Jun 2002

Scott M Cathy, Wakamatsu Kazumasa, Ito Shosuke, Kadekaro Ana Luisa, Kobayashi Nobuhiko, Groden Joanna, Kavanagh Renny, Takakuwa Takako, Virador Victoria, Hearing Vincent J, Abdel-Malek Zalfa A

Abstract excerpt

Cutaneous pigmentation is determined by the amounts of eumelanin and pheomelanin synthesized by epidermal melanocytes and is known to protect against sun-induced DNA damage. The synthesis of eumelanin is stimulated by the binding of alpha-melanotropin (alpha-melanocyte-stimulating hormone) to the functional melanocortin 1 receptor (MC1R) expressed on melanocytes. The human MC1R gene is highly polymorphic and...

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Identifiers

PMID: 12006619
DOI: 10.1242/jcs.115.11.2349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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