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Article

The Melanocortin 1 Receptor and the UV Response of Human Melanocytes—A Shift in Paradigm<sup>†</sup>

12 Feb 2008

Abstract excerpt

Cutaneous pigmentation is the major photoprotective mechanism against the carcinogenic and aging effects of UV. Epidermal melanocytes synthesize the pigment melanin, in the form of eumelanin or pheomelanin. Synthesis of the photoprotective eumelanin by human melanocytes is regulated mainly by the melanocortins alpha-melanocortin (alpha-MSH) and adrenocorticotropic hormone (ACTH), which bind the melanocortin 1...

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Identifiers

PMID: 18282187
DOI: 10.1111/j.1751-1097.2008.00294.x

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