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Article

Melanin content and MC1R function independently affect UVR‐induced DNA damage in cultured human melanocytes

24 May 2006

Abstract excerpt

Malignant transformation of melanocytes leads to melanoma, the most fatal form of skin cancer. Ultraviolet radiation (UVR)-induced DNA photoproducts play an important role in melanomagenesis. Cutaneous melanin content represents a major photoprotective mechanism against UVR-induced DNA damage, and generally correlates inversely with the risk of skin cancer, including melanoma. Melanoma risk is also determined by...

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PMID: 16827749
DOI: 10.1111/j.1600-0749.2006.00315.x

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