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Article

Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.

European journal of biochemistry - 1 Dec 2002

Sánchez Más Jesús, Olivares Sánchez Concepción, Ghanem Ghanem, Haycock John, Lozano Teruel José Antonio, García-Borrón José Carlos, Jiménez-Cervantes Celia

Abstract excerpt

The alpha-melanocyte-stimulating hormone (alphaMSH) receptor (MC1R) is a major determinant of mammalian skin and hair pigmentation. Binding of alphaMSH to MC1R in human melanocytes stimulates cell proliferation and synthesis of photoprotective eumelanin pigments. Certain MC1R alleles have been associated with increased risk of melanoma. This can be theoretically considered on two grounds. First, gain-of-function...

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Identifiers

PMID: 12473109
DOI: 10.1046/j.1432-1033.2002.03329.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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