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Article

CpG island methylation in aberrant crypt foci of the colorectum.

The American journal of pathology - 1 May 2002

Chan Annie On-On, Broaddus Russell R, Houlihan Patrick S, Issa Jean-Pierre J, Hamilton Stanley R, Rashid Asif

Abstract excerpt

Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG island methylation has been described as an important molecular pathway. We therefore studied methylation in ACF from patients with familial adenomatous polyposis (FAP) or sporadic colorectal cancer. We assessed methylation status of the p16 tumor suppressor gene, MINT1 (methylated in tumor 1),...

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Share to Chromosomes, Human, Pair 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12000733
DOI: 10.1016/S0002-9440(10)61128-5
PMCID: PMC1850869

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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