Article
BRAF mutations in aberrant crypt foci and hyperplastic polyposis.
The American journal of pathology - 1 Apr 2005
Beach Robyn, Chan Annie On-On, Wu Tsung-Teh, White Jill A, Morris Jeffrey S, Lunagomez Simon, Broaddus Russell R, Issa Jean-Pierre J, Hamilton Stanley R, Rashid Asif
Abstract excerpt
Patients with hyperplastic polyposis have multiple hyperplastic polyps (HPs) and increased risk of colorectal carcinomas. Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesions in colorectal carcinogenesis. We evaluated BRAF mutations by DNA sequencing in 53 ACF from patients with sporadic colorectal carcinomas and familial adenomatous polyposis, in 18 sporadic HPs from patients with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.