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Article

Aberrant crypt foci as precursors in colorectal cancer progression

11 Jul 2008

Abstract excerpt

Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high-magnification chromoscopic colonoscopy. ACF are biomarkers of increased colorectal cancer risk, particularly those...

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PMID: 18623110
DOI: 10.1002/jso.21106

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