Article
Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2008
Kukitsu Takehiro, Takayama Tetsuji, Miyanishi Koji, Nobuoka Atsushi, Katsuki Shinichi, Sato Yasushi, Takimoto Rishu, Matsunaga Takuya, Kato Junji, Sonoda Tomoko, Sakamaki Sumio, Niitsu Yoshiro
Abstract excerpt
PURPOSE: Long-standing ulcerative colitis (UC) predisposes patients to the development of colorectal cancer, but surveillance of colitis-associated cancer by detecting the precancerous lesion dysplasia is often difficult because of its rare occurrence and normal-looking appearance. In sporadic colorectal cancer, aberrant crypt foci (ACF) have been reported by many investigators to be precursor lesions of the...
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