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Article

Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.

Science (New York, N.Y.) - 3 May 2002

Sillaber Inge, Rammes Gerhard, Zimmermann Stephan, Mahal Beatrice, Zieglgänsberger Walter, Wurst Wolfgang, Holsboer Florian, Spanagel Rainer

Abstract excerpt

There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior...

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Source

Identifiers

PMID: 11988580
DOI: 10.1126/science.1069836

Genes

CRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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