Article
Bidirectional relationship between alcohol intake and sensitivity to social defeat: association with Tacr1 and Avp expression.
Addiction biology - 1 Jan 2018
Nelson Britta S, Sequeira Michelle K, Schank Jesse R
Abstract excerpt
While epidemiological studies show that alcohol abuse is often co-morbid with affective disorders, the causal direction of this association is unclear. We examined this relationship using mouse models including social defeat stress (SDS), social interaction (SI) and voluntary alcohol consumption. C57BL6/J mice exposed to SDS segregate into two subpopulations, those that express depressive-like phenotypes...
Topics
- Alcohol Drinking
- Alcoholism
- Animals
- Arginine Vasopressin
- Behavior, Animal
- Brain
- Depression
- Epigenesis, Genetic
- Genetic Predisposition to Disease
- Interpersonal Relations
- Male