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Article

Steroid receptor coactivator-1 is necessary for regulation of corticotropin-releasing hormone by chronic stress and glucocorticoids.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2009

Lachize Servane, Apostolakis Ede M, van der Laan Siem, Tijssen Ans M I, Xu Jianming, de Kloet E Ronald, Meijer Onno C

Abstract excerpt

Adaptation to stress in vertebrates occurs via activation of hormonal and neuronal signaling cascades in which corticotropin-releasing hormone (CRH) plays a central role. Expression of brain CRH is subject to strong, brain-region specific regulation by glucocorticoid hormones and neurogenic intracellular signals. We hypothesized that Steroid Receptor Coactivator 1 (SRC-1), a transcriptional coregulator of the...

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Source

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Identifiers

PMID: 19416907
DOI: 10.1073/pnas.0812062106
PMCID: PMC2683087

Genes

CRH
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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