HPA axis dysregulation in mice overexpressing corticotropin releasing hormone.

doi:10.1016/s0006-3223(02)01334-3

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Article

HPA axis dysregulation in mice overexpressing corticotropin releasing hormone.

Biological psychiatry - 1 Jun 2002

Groenink Lucianne, Dirks Anneloes, Verdouw P Monika, Schipholt Marlies lutje, Veening Jan G, van der Gugten Jan, Olivier Berend

Abstract excerpt

BACKGROUND: Hypersecretion of corticotropin-releasing hormone (CRH) in the brain has been implicated in stress-related human pathologies. We developed a transgenic mouse line overexpressing CRH (CRH-OE) exclusively in neural tissues to assess the effect of long-term CRH overproduction on regulation of the hypothalamic-pituitary-adrenal (HPA) axis. METHODS: Male transgenic CRH-OE(2122) mice on a C57BL/6J...

Topics

Adrenocorticotropic Hormone
Animals
Corticotropin-Releasing Hormone
Gene Expression Regulation
Genotype
Hypothalamo-Hypophyseal System
Mice
Mice, Transgenic
Pituitary-Adrenal System
Stress, Physiological

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PMID: 12022960
DOI: 10.1016/s0006-3223(02)01334-3

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