Article
Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice.
Psychopharmacology - 1 Nov 2011
Pastor Raúl, Reed Cheryl, Burkhart-Kasch Sue, Li Na, Sharpe Amanda L, Coste Sarah C, Stenzel-Poore Mary P, Phillips Tamara J
Abstract excerpt
RATIONALE: Exposure to stressors promotes ethanol (EtOH) consumption and enhances drug craving during abstinence. Corticotropin-releasing factor (CRF), and in particular, CRF actions via type 1 CRF receptors (CRF(1)) are critical in behavioral responses to stressors. CRF(1) play a role in EtOH-induced behavioral neuroadaptation, in binge-like EtOH consumption, and in heightened EtOH consumption in dependent...
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