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Article

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

Nature neuroscience - 1 Oct 2003

Müller Marianne B, Zimmermann Stephan, Sillaber Inge, Hagemeyer Thomas P, Deussing Jan M, Timpl Peter, Kormann Michael S D, Droste Susanne K, Kühn Ralf, Reul Johannes M H M, Holsboer Florian, Wurst Wolfgang

Abstract excerpt

Corticotropin-releasing hormone (CRH) is centrally involved in coordinating responses to a variety of stress-associated stimuli. Recent clinical data implicate CRH in the pathophysiology of human affective disorders. To differentiate the CNS pathways involving CRH and CRH receptor 1 (Crhr1) that modulate behavior from those that regulate neuroendocrine function, we generated a conditional knockout mouse line...

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Source

Identifiers

PMID: 12973355
DOI: 10.1038/nn1123

Genes

CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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