Article

Patched regulates cell cycle and tissue architecture in C. elegans gonad

2025-06-10

Abstract excerpt

Hedgehog (Hh) signaling is essential for embryonic development and tissue homeostasis in several organisms. However, Caenorhabditis elegans lacks canonical Hh signaling due to the absence of key components, such as smoothened (SMO) and Hh ligands. Despite this, C. elegans retains Patched homologs, ptc-1 and ptc-3, which have specialized independent functions. Although ptc-1 is predominantly expressed in the gonads...

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Literature Corpus work: 1a7a2902-e3b4-5bde-8256-d9bde955a8f7
DOI: 10.1101/2025.06.09.657693

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