Article
Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Calderwood David A, Fujioka Yosuke, de Pereda Jose M, García-Alvarez Begoña, Nakamoto Tetsuya, Margolis Ben, McGlade C Jane, Liddington Robert C, Ginsberg Mark H
Abstract excerpt
The cytoplasmic domains (tails) of heterodimeric integrin adhesion receptors mediate integrins' biological functions by binding to cytoplasmic proteins. Most integrin beta tails contain one or two NPXYF motifs that can form beta turns. These motifs are part of a canonical recognition sequence for phosphotyrosine-binding (PTB) domains, protein modules that are present in a wide variety of signaling and...
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