The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation.

doi:10.1074/jbc.M117.776195

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Article

The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation.

The Journal of biological chemistry - 25 Aug 2017

Hirbawi Jamila, Bialkowska Katarzyna, Bledzka Kamila M, Liu Jianmin, Fukuda Koichi, Qin Jun, Plow Edward F

Abstract excerpt

Kindlin-2 (K2), a 4.1R-ezrin-radixin-moesin (FERM) domain adaptor protein, mediates numerous cellular responses, including integrin activation. The C-terminal 15-amino acid sequence of K2 is remarkably conserved across species but is absent in canonical FERM proteins, including talin. In CHO cells expressing integrin αIIbβ3, co-expression of K2 with talin head domain resulted in robust integrin activation, but...

Topics

Amino Acid Substitution
Animals
CHO Cells
Cell Line, Tumor
Cricetulus
Gene Deletion
Humans
Integrin alpha2
Integrin beta3
Leukemia, Erythroblastic, Acute
Luminescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophages

Membrane Proteins

Mice

Mutation

Neoplasm Proteins

Peptide Fragments

Protein Interaction Domains and Motifs

Source

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Identifiers

PMID: 28652408
DOI: 10.1074/jbc.M117.776195
PMCID: PMC5572925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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