Article
Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2002
Deng Hong-Wen, Shen Hui, Xu Fu-Hua, Deng Hong-Yi, Conway Theresa, Zhang Hai-Tao, Recker Robert R
Abstract excerpt
Bone mineral density (BMD) is a major determinant of osteoporotic fractures (OFs). The heritability of BMD ranges from 50% to 90% in human populations. Extensive molecular genetic analyses have been performed through traditional linkage or association approaches to test and identify genes or genomic regions underlying BMD variation. The results, particularly those concerning the vitamin D receptor (VDR) gene,...
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