Article
Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis.
The Journal of clinical endocrinology and metabolism - 1 Sept 2000
Koller D L, Econs M J, Morin P A, Christian J C, Hui S L, Parry P, Curran M E, Rodriguez L A, Conneally P M, Joslyn G, Peacock M, Johnston C C, Foroud T
Abstract excerpt
A major determinant of the risk for osteoporosis is peak bone mineral density (BMD), which is largely determined by genetic factors. We recently reported linkage of peak BMD in a large sample of healthy sister pairs to chromosome 11q12-13. To identify additional loci underlying normal variations in peak BMD, we conducted an autosomal genome screen in 429 Caucasian sister pairs. Multipoint LOD scores were computed...
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