Article
Genetic determination of osteoporosis: lessons learned from a large genome-wide linkage study.
Human biology - 1 Dec 2007
Xiong Dong-Hai, Wang Jin-Tang, Wang Wei, Guo Yan-Fang, Xiao Peng, Shen Hui, Jiang Hui, Chen Yuan, Deng Hongyi, Drees Betty, Recker Robert R, Deng Hong-Wen
Abstract excerpt
Osteoporosis is a common disease with strong genetic control. We performed an autosomal linkage scan in a large pedigree-based sample of 4,498 subjects for a composite osteoporosis phenotype that combines osteoporotic fracture (OF) and low bone mineral density (BMD). All of the subjects were U.S. Caucasians recruited in the Omaha area of Nebraska. Sex-specific linkage analyses and autosomal imprinting analyses...
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